• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Closed and sterile device for separation and aseptic concentration of biological components; comprising, at least: - a tube (1) closed by a first end (11) and having a mouth (12) at a second end; - a plunger (2) of flexible material, without actuating rod, mounted inside the tube (1) with the possibility of longitudinal movement and having a hole (21) for loading a fluid to be separated and concentrated, and discharge of the separated fractions, whose orifice (21) is provided with a valved female luer-lock connection (22); and a purge conduit (23), provided with a self-sealing filter (24) for the automatic purge of the air/gas contained in the tube (1) during the filling of the tube (1) with the fluid to be separated and concentrated; and - a plug (3) for protecting the connection/plunger assembly, which can be coupled to the mouth of the tube. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2675279A1
    申请号:ES201631598
    申请日:2016-12-16
    公开日:2018-07-10
    发明作者:Guillermo GARAU ESPINÓS
    申请人:Guillermo GARAU ESPINÓS；
    IPC主号:
    专利说明:

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    Understanding the characteristics of the invention, a set of drawings is attached to the present specification in which, for illustrative and non-limiting purposes, the following has been represented:
    -Figure 1 shows an elevation view of an example of embodiment of the closed and sterile device for the separation of aseptic concentration of biological components, with the cap in the open position.
    -Figure 2 shows an exploded elevation view of the device of the previous figure, sectioned by a vertical plane.
    -Figure 3 shows an elevation view of the device of the previous figures during the loading of the fluid to be separated inside the tube by means of a loading syringe provided with a male "luer-lock" connection, complementary to the "luer-" connection. lock ”female valve piston, and coupled with it.
    -Figure 4 shows a view of the device in the closed position once centrifuged, being able to observe the buoy located between the two fractions of liquid of different density, separated and concentrated.
    -Figure 5 shows a view of the device of the previous figures during the extraction of one of the liquid fractions by means of an extraction syringe coupled to the luer-lock connection of the plunger, and establishing said piston contact, by means of its perimeter lip , with the perimeter chamfer of the buoy. Preferred embodiment of the invention.
    As can be seen in Figure 1, the closed and sterile device for the separation and aseptic concentration of biological components; It comprises a tube (1) with a first end (11) closed and having a mouth (12) at a second end.
    Inside the tube (1) it is mounted with the possibility of displacement


    longitudinally a piston (2) of flexible material, without drive rod.
    Said plunger (2) has an orifice (21) for loading a fluid to be separated and concentrated in various fractions, and for discharging the fractions of said fluid, of different density, separated by centrifugation.
    The orifice (21) has at the end oriented towards the mouth (12) of the tube (1) of a female luer-lock connection (22), whose valve is normally held in a closed position and opens when coupled with a luer-lock male connection (CM).
    The piston (2) also has a conduit (23) for automatic purging of the air / gas contained in the tube (1) during the filling of the tube (1) with the fluid to be separated and concentrated, this filling operation being carried out by means of a loading syringe (JC) provided with a male "luer-lock" connection (CM) complementary to that of the piston (2), as shown in Figure 3.
    Said purge conduit (23) is provided with a self-sealing filter (24) comprising a gelling filler which, when in contact with the fluid to be separated due to the complete filling of the tube (1) and is moistened with said fluid, gels and Seals immediately, losing its permeability to air / gas and liquids.
    The piston (2) has a concave anterior end (25), oriented towards the first end (11) of the tube (1) and provided with radial fins (25), which avoid turbulence and favor precise fractionation, stabilizing the passage of the liquid fraction separated from inside the tube (1) to an extraction syringe (JE) coupled to the female "luer-lock" connection (22) valved from the plunger (2) by means of a male "luer-lock" connection (CM) complementary, as shown in Figure 5. This extraction syringe (JE) has a smaller diameter than the tube (1) acting in the coupling position as the piston rod (2).


    The piston has on its side surface a perimeter recess (27) defined between adjusting rings (28) with the inside of the tube (1).
    The device comprises a protection plug (3) of the connection / piston assembly, attachable to the mouth (12) of the tube (1).
    This protective cap (3) incorporates in its interior an absorbent filler (31) that protects and dries the female luer-lock connection (22) of the piston (2) from possible drops of the fluids to be separated and concentrated, avoiding contamination risks .
    The device of the invention comprises inside the tube (1) a plastic cylindrical buoy (4), of a predetermined density and provided with a central hole (41) with a unidirectional valve (42) for the passage of the fractions more dense towards the area below the buoy; said buoy forming a physical barrier between fractions of different density, once separated by centrifugation, as shown in Figure 4.
    Said buoy (4) has a concave upper face (43) that ends, internally, in the central hole (41) of fluid passage through the buoy (2) and, externally, in a perimeter chamfer (44).
    The mission of this perimeter chamfer (44) is to cause a lateral expansion of the perimeter lip (29) of the piston (2) and the braking of the advance of the piston (2) inside the tube (1) when, said piston (2) , contact the buoy (4) during the extraction of one of the separate liquid fractions, as shown in Figure 5.
    To perform the extraction of the liquid fraction above the buoy
    (4) it is enough to move the piston (2) towards the lower zone, pushing it with the extraction syringe (JE) and keeping the rod of said extraction syringe free so that, said rod, it can move freely upwards as that the liquid fraction accesses inside said syringe.
    Once the nature of the invention has been sufficiently described, as well as an example
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    权利要求:
    Claims (1)
    [1]
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    类似技术:
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    ES2675279A1|2018-07-10|CLOSED AND STERILE DEVICE FOR SEPARATION AND ASEPTIC CONCENTRATION OF BIOLOGICAL COMPONENTS. |
    ECSP11011476A|2012-03-30|INTRAVENOUS TEAM WITH AN AUTOMATIC DETENTION MECHANISM WITHIN THE DRIP CHAMBER
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    同族专利:
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    ES2879837T3|2021-11-23|
    EP3556292A1|2019-10-23|
    WO2018109246A1|2018-06-21|
    PT3556292T|2021-06-23|
    RU2718314C1|2020-04-01|
    CA3045894A1|2018-06-21|
    US20200069521A1|2020-03-05|
    EP3556292A4|2020-05-13|
    ES2675279B2|2018-12-21|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20140358033A1|1998-05-29|2014-12-04|Lawrence A. Lynn|Luer Receiving Air Evacuated Blood Collector|
    US6849052B2|1999-12-13|2005-02-01|Arkray, Inc.|Body fluid measuring apparatus with lancet and lancet holder used for the measuring apparatus|
    EP2077115A1|2006-10-27|2009-07-08|Nipro Corporation|Platelet-rich plasma separator and platelet-rich plasma separation method|
    US20110008978A1|2009-07-09|2011-01-13|Tyco Electronics Corporation|Electrical connector for a solar module assembly|
    ES2437541B1|2012-07-03|2014-11-25|Biotechnology Institute, I Mas D, S.L.|Device for the extraction, storage and / or processing of blood or other substances of human or animal origin, and for the application of blood compounds or other biological compounds|
    US3735900A|1971-05-13|1973-05-29|Prod Res & Chem Corp|Dual ingredient storage, intermixing and dispensing storage|
    US4644807A|1985-02-21|1987-02-24|Dionex Corporation|Fluid sample delivery apparatus|
    US4936315A|1988-10-20|1990-06-26|Lineback Paul I|Methods and apparatus for obtaining arterial blood samples|
    AU2003249642A1|2002-05-24|2003-12-12|Biomet Manufacturing Corp.|Apparatus and method for separating and concentrating fluids containing multiple components|
    ES1059764Y|2005-03-07|2005-09-16|Fabo M Dolores Espinos|DEVICE FOR SEPARATION AND RECOVERY OF FLUIDS IN MEDICINE.|
    US7927563B1|2009-10-13|2011-04-19|Cytomedix, Inc.|Kit for separation of biological fluids|
    US9804070B2|2013-03-26|2017-10-31|Alliance Partners, Llc|Biological fluids concentration assembly|
    法律状态:
    2018-07-10| BA2A| Patent application published|Ref document number: 2675279 Country of ref document: ES Kind code of ref document: A1 Effective date: 20180710 |
    2018-12-21| FG2A| Definitive protection|Ref document number: 2675279 Country of ref document: ES Kind code of ref document: B2 Effective date: 20181221 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201631598A|ES2675279B2|2016-12-16|2016-12-16|CLOSED AND STERILE DEVICE FOR THE SEPARATION AND ASEPTIC CONCENTRATION OF BIOLOGICAL COMPONENTS|ES201631598A| ES2675279B2|2016-12-16|2016-12-16|CLOSED AND STERILE DEVICE FOR THE SEPARATION AND ASEPTIC CONCENTRATION OF BIOLOGICAL COMPONENTS|
    US16/468,131| US11071690B2|2016-12-16|2017-11-20|Sealed sterile device for the aseptic separation and concentration of biological components|
    EP17881166.7A| EP3556292B1|2016-12-16|2017-11-22|Sealed sterile device for the aseptic separation and concentration of biological components|
    CA3045894A| CA3045894A1|2016-12-16|2017-11-22|Sealed sterile device for the aseptic separation and concentration of biological components|
    PCT/ES2017/070768| WO2018109246A1|2016-12-16|2017-11-22|Sealed sterile device for the aseptic separation and concentration of biological components|
    ES17881166T| ES2879837T3|2016-12-16|2017-11-22|Sterile, closed device for the aseptic separation and concentration of biological components|
    PT178811667T| PT3556292T|2016-12-16|2017-11-22|Sealed sterile device for the aseptic separation and concentration of biological components|
    RU2019118386A| RU2718314C1|2016-12-16|2017-11-22|Hermetically sealed device for aseptic separation and concentration of biological components|
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